Hiperceratose epidermolítica: um seguimento de 23 anos de uso de retinoides orais

Epidermolytic hyper ke ra to sis is a form of ichth yo sis nor mally resis tant to topi cal treat ments. Female patient moni to red since 1978 diag no sed with epi der moly tic hyper ke ra to sis. Clinical exa mi na tion sho wed gene ra li zed hyper ke ra to sis and sca ling. Given that no other treat ments were avai la ble at the time, the patient was ini tially trea ted with kera toly tic, syste mic vita min A and mois tu ri zers, with no impro ve ment. In 1986, with the deve lop ment of oral reti noids, etre ti na te was intro du ced. In 1998 this was repla ced by aci tre tin. The patient is recei ving 25 mg/day after 23 years of using oral reti noids. Significant impro ve ment of the con di tion and patient ́s qua lity of life has been noted.